Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

How is it possible to think new thoughts? What is creativity and can science explain it? And just how did Coleridge dream up the creatures of The Ancient Mariner? When The Creative Mind: Myths and Mechanisms was first published, Margaret A. Boden's bold and provocative exploration of creativity broke new ground. Boden uses examples such as jazz improvisation, chess, story writing, physics, and the music of Mozart, together with computing models from the field of artificial intelligence to uncover the (...) nature of human creativity in the arts. The second edition of The Creative Mind has been updated to include recent developments in artificial intelligence, with a new preface, introduction and conclusion by the author. It is an essential work for anyone interested in the creativity of the human mind. (shrink)

An essential work for anyone interested in the creativity of the human mind, "The Creative Mind" has been updated to include recent developments in artificial ...

In a compelling chronicle of her search to understand Beauvoir's philosophy in The Second Sex, Margaret A. Simons offers a unique perspective on Beauvoir's wide-ranging contribution to twentieth-century thought. She details the discovery of the origins of Beauvoir's existential philosophy in her handwritten diary from 1927; uncovers evidence of the sexist exclusion of Beauvoir from the philosophical canon; reveals evidence that the African-American writer Richard Wright provided Beauvoir with the theoretical model of oppression that she used in The Second (...) Sex; shows the influence of The Second Sex in transforming Sartre's philosophy and in laying the theoretical foundations of radical feminism; and addresses feminist issues of racism, motherhood, and lesbian identity. Simons also draws on her experience as a Women's Liberation organizer as she witnessed how women used The Second Sex in defining the foundations of radical feminism. Bringing together her work as both activist and scholar, Simons offers a highly original contribution to the renaissance of Beauvoir scholarship. (shrink)

What is the mind? How does it work? How does it influence behavior? Some psychologists hope to answer such questions in terms of concepts drawn from computer science and artificial intelligence. They test their theories by modeling mental processes in computers. This book shows how computer models are used to study many psychological phenomena--including vision, language, reasoning, and learning. It also shows that computer modeling involves differing theoretical approaches. Computational psychologists disagree about some basic questions. For instance, should the mind (...) be modeled by digital computers, or by parallel-processing systems more like brains? Do computer programs consist of meaningless patterns, or do they embody (and explain) genuine meaning? (shrink)

This interdisciplinary collection of classical and contemporary readings provides a clear and comprehensive guide to the many hotly-debated philosophical issues at the heart of artificial intelligence.

The applications of Artificial Intelligence lie all around us; in our homes, schools and offices, in our cinemas, in art galleries and - not least - on the Internet. The results of Artificial Intelligence have been invaluable to biologists, psychologists, and linguists in helping to understand the processes of memory, learning, and language from a fresh angle.As a concept, Artificial Intelligence has fuelled and sharpened the philosophical debates concerning the nature of the mind, intelligence, and the uniqueness of human beings. (...) Margaret A. Boden reviews the philosophical and technological challenges raised by Artificial Intelligence, considering whether programs could ever be really intelligent, creative or even conscious, and shows how the pursuit of Artificial Intelligence has helped us to appreciate how human and animal minds are possible. (shrink)

This new volume in the acclaimed Oxford Readings in Philosophy sereis offers a selection of the most important philosophical work being done in the new and fast-growing interdisciplinary area of artificial life. Artificial life research seeks to synthesize the characteristics of life by artificial means, particularly employing computer technology. The essays here explore such fascinating themes as the nature of life, the relation between life and mind, and the limits of technology.

Margaret Boden presents a series of essays in which she explores the nature of creativity in a wide range of art forms. Creativity is the generation of novel, surprising, and valuable ideas. Boden identifies three forms of creativity each eliciting a different form of surprise.

Along the way, she calls upon us to recognize the mysteries that lie at the heart of our lives and the metaphysical reality that gives meaning to life.The ...

Feminist philosophy seems to conflict with traditional philosophical methodology. For example, some uses of the concept of gender by feminist philosophers seem to commit the genetic fallacy. I argue that use of the concept of gender need not commit the genetic fallacy, but that the concept of gender is problematic on other grounds.

Addressing central questions in the debate about Foucault's usefulness for politics, including his rejection of universal norms, his conception of power and power-knowledge, his seemingly contradictory position on subjectivity and his ...

This book offers an historical and critical guide to the concepts of the post-modern and the post-industrial. It brings admirable clarity and thoroughness to a discussion of the many different uses made of the term post-modern across a number of different disciplines (including literature, architecture, art history, philosophy, anthropology and geography). It also analyses the concept of the post-industrial society to which the concept of the post-modern has often been related. Dr Rose discusses the work of many theorists in the (...) area, including Hassan, Lyotard, Jameson and the architectural historian Charles Jencks, and also looks at analyses and uses of the concepts of the post-modern and post-industrial by Frampton, Portoghesi, Peter Fuller and others. (shrink)

The topic of this chapter, the early philosophical influence of Henri Bergson (1859-1941) on Simone de Beauvoir, may surprise those who remember Beauvoir’s reference to Bergson in her Memoirs of a Dutiful Daughter where she denies Bergson’s importance. She writes there of her interests in 1926: “I preferred literature to philosophy, and I would not have been at all pleased if someone had prophesized that I would become a kind of Bergson; I didn’t want to speak with that abstract voice (...) which, whenever I heard it, failed to move me.” But in this case, as in so many others, Beauvoir’s diaries present a very different picture. Her unpublished 1926 diary, written when Beauvoir was eighteen years old and beginning her study of philosophy, contains several pages of quotations from Bergson’s Time and Free Will: An Essay on the Immediate Data of Consciousness (1889), which Beauvoir describes, in an entry dated August 16, as “a great intellectual intoxication.” The entry continues: “whereas in reading other philosophers I have the impression of witnessing more or less logical constructions, here finally I am touching palpable reality and encountering life. Not only myself, but art, the truths suggested by poets, and everything that I studied this year is magnificently explained. Simply a call to intuition…. in short the method that I spontaneously apply when I want to know myself and the most difficult problems disappear. How many things [there are] in the 180 pages of Bergson’s The immediate givens of consciousness” Intriqued by this diary passage, I began analyzing Beauvoir’s early philosophy for evidence of Bergson’s influence, focusing on Bergson’s three most important texts: Time and FreeWill (1889), Matter and Memory: An Essay on the Relation of the Body to the Mind (1896), and Creative Evolution (1907). My analysis uncovered evidence of Bergson’s influence in several of Beauvoir’s important early texts, especially She Came to Stay, Beauvoir’s metaphysical novel written from 1937 to 1941, but also Beauvoir’s essays in existential ethics and The Second Sex (1949). Indeed Bergson now seems to me to be a key to understanding the roots of Beauvoir’s philosophy. In this paper, I will narrow my focus to Bergson’s philosophical methodology, and its influence on She Came to Stay, identifying three Bergsonian elements of Beauvoir’s philosophical methodology. First of all, Beauvoir takes seriously Bergson's criticism of intellectual understanding and accepts his implicit challenge to do philosophy through the novel. Secondly, Beauvoir shares with Bergson a methodological interest in exposing distortions in perception and thinking. Finally, they both rely on a methodological turn to immediate experience, which discloses our freedom. Beauvoir did not follow Bergson completely or uncritically. She did not follow him, for example, in the vitalist system building of Creative Evolution or the mysticism of his later work, Two Sources of Morality and Religion. In Beauvoir’s short story cycle, When Things of the Spirit Come First, written from 1935-37, which Beauvoir describes as “clarifying the genesis” of her later work, (QPS, viii) she satirizes her early intellectual passions, including Paul Claudel’s morality of feminine self-sacrifice, André Breton’s Surrealism, and Bergson's philosophy. Furthermore, Beauvoir’s early work, including She Came to Stay, focuses on an aspect of reality ignored by Bergson’s early work, i.e. the problem of the opposition of self and other. (shrink)

Since her death in 1986 and the publication of her letters and diaries in 1990, interest in the philosophy of Simone de Beauvoir has never been greater. In this engaging and timely volume, Margaret A. Simons and an international group of philosophers present 16 essays that reveal Beauvoir as one of the century’s most important and influential thinkers. As they set Beauvoir’s work into dialogue with Husserl, Merleau-Ponty, Heidegger, Foucault, Levinas, and others, these essays consider questions such as Beauvoir’s (...) philosophical relationship with Sartre; her ethic of the erotic; her views on marriage, motherhood, and female friendship; and her interpretations of oppression and liberation. This book discusses the full range of Beauvoir’s work, including The Second Sex, her unpublished diaries, autobiographical writings, novels, and philosophical essays, and broadens the scope and interpretive context of her unique philosophy. Contributors are Nancy Bauer, Debra Bergoffen, Suzanne Laba Cataldi, Edward Fullbrook, Eva Gothlin, Sara Heinämaa, Laura Hengehold, Stacy Keltner, Michèle Le Doeuff, Ann Murphy, Shannon M. Mussett, Margaret A. Simons, Ursula Tidd, Andrea Veltman, Karen Vintges, Julie Ward, Gail Weiss. (shrink)

New technologies are changing our lives radically and quickly. New biotechnologies are moving to commercial uses faster than government regulators or private citizens can monitor. This tension manifests itself in the current debates over xenotransplantation technologies in medicine. The possibility of removing cells, tissues, and organs from animals and transplanting them into human beings is startling and unnerving. Natural immunesystem barriers between species, and even between individuals within a species, are formidable. Typically, transplantation results in violent rejection and death of (...) the grafted organ. But despite the natural barriers to transplantation, xenotransplantation aims specifically to overcome them.In this paper, I will discuss applications of xenograft technology, which raises clinical risks, ethical concerns, and policy issues. I conclude with a set of specific recommendations. As a recent letter to the journal Nature puts it, there is a “split between those who want to get it right, and those who want to get it right now.” No one knows what all the risks, benefits, and unintended consequences of xenotransplantation will be. (shrink)

New technologies are changing our lives radically and quickly. New biotechnologies are moving to commercial uses faster than government regulators or private citizens can monitor. This tension manifests itself in the current debates over xenotransplantation technologies in medicine. The possibility of removing cells, tissues, and organs from animals and transplanting them into human beings is startling and unnerving. Natural immunesystem barriers between species, and even between individuals within a species, are formidable. Typically, transplantation results in violent rejection and death of (...) the grafted organ. But despite the natural barriers to transplantation, xenotransplantation aims specifically to overcome them.In this paper, I will discuss applications of xenograft technology, which raises clinical risks, ethical concerns, and policy issues. I conclude with a set of specific recommendations. As a recent letter to the journal Nature puts it, there is a “split between those who want to get it right, and those who want to get it right now.” No one knows what all the risks, benefits, and unintended consequences of xenotransplantation will be. (shrink)

Teaching chemistry remains a profoundly challenging activity. This paper arises from reflection on the challenges of creating meaningful assessments. Herein a simple framework to assist in making more visible the different kinds of knowledge required for mastery of chemistry is described. Building from a realist foundation the purpose of this paper is to lay the intellectual scaffolding for the framework. By situating the framework theoretically, it is intended to highlight the value of engaging with philosophy for the project of knowledge (...) building in chemistry. Use of this framework has laid bare some significant limitations to the ways in which organic chemistry has been assessed. Making the visible to students aids in their engagement with knowledge and for a small minority has developed their understanding of science more generally. The framework provides a simple, easily usable tool for the evaluation of chemistry assessments. (shrink)

Our physical ecosystem is not indestructible and we have obligations to hold it in trust for future generations. The same is true of our metaphysical ecosystem - the values, principles, attitudes, beliefs, and shared stories on which we have founded our society. In Bird on an Ethics Wire, Margaret Somerville explores the values needed to maintain a world that reasonable people would want to live in and pass on to their descendants. Somerville addresses the conflicts between people who espouse (...) "progressive" values and those who uphold "traditional" ones by casting her attention on the debates surrounding "birth" and "death" and shows how words are often used as weapons. She proposes that we should seek to experience amazement, wonder, and awe to enrich our lives and help us to find meaning. Such experiences, Somerville believes, can change how we see the world and live our lives, and affect the decisions we make, especially regarding values and ethics. They can help us to cope with physical or existential suffering, and ultimately put us in touch with the sacred - in either its secular or religious form - which protects what we must not destroy. Experiencing amazement, wonder, and awe, Somerville concludes, can also generate hope, without which our spirit dies. Both individuals and societies need hope, a sense of connection to the future, if the world is to make the best decisions about values in the battles that constitute the current culture wars. (shrink)

This book offers an original and challenging study of Marx's contact with the visual arts, aesthetic theories, and art policies in nineteenth-century Europe. It differs from previous discussions of Marxist aesthetic theory in looking at Marx's views from an art-historical rather than from a literary perspective, and in placing those views in the context of the art practices, theories, and policies of Marx's own time. Dr Rose begins her work by discussing Marx's planned treatise on Romantic art of 1842 against (...) the background of the philosophical debates, cultural policies, and art practices of the 1840s, and looks in particular at the patronage given to the group of German artists known as the 'Nazarenes' in those years, who are discussed in relation to both the English Pre-Raphaelites, popular in the London known to Marx, and to the Russian Social Realists of the 1860s. The author goes on to consider claims of twentieth-century Marxist art theories and practices to have represented Marx's own views on art. The book the conflicting claims made on Marx's views by the Soviet avant-garde Constructivists of the 1920s and of the Socialist Realists who followed them are considered, and are related back to the aesthetic theories and practices discussed in the earlier chapters. (shrink)

This brief response aims to contextualize and reflect further on James Gustafson's new essay regarding “participation” in relation to God, nature, and human beings. In it I attempt to address Gustafson's innovative method and the difference it makes for interpreting some of his previous work. For the first time Gustafson's direct mode of access to the meaning and implications of human participation is through his own experience. I argue that he breaks new ground with what might be called descriptive experiential (...) analysis, moving forward yet harking back to longtime central themes regarding knowledge of God, moral discernment, theocentrism and anthropocentrism, relationalism and unity. (shrink)

Transnational feminism should have normative force and be anti‐imperialist. This article addresses the possibility of an anti‐imperialist transnational feminism in conversation with Serene Khader’s Decolonizing Universalism. Khader argues that the key to an anti‐imperialist feminism is separating universalism from the features that result in imperialism, such as ethnocentrism and justice monism. This article shares Khader’s commitment to anti‐imperialist feminism and further explores three relevant issues: human rights, the definition of feminism, and economic justice. It proposes a decolonizing view of rights (...) that advocates a critical examination of their uses, applications, and origins. It argues that transnational feminism should engage with issues of economic justice. And it proposes that feminism as an intersectional praxis should include normative dimensions in addition to antisexism, such as antiracism and economic justice. (shrink)

The posthumously published diaries and letters of Beauvoir and Sartre challenge the traditional account of Beauvoir as Sartre's philosophical follower. They show Sartre drawing on Beauvoir's account of relations with the Other in her metaphysical novel, She Came to Stay, as he began writing Being and Nothingness, and point to an unexplored Beauvoirean lineage of existentialism, including Bergson as well as Hegel, Kierkegaard, Husserl and Heidegger, and the African-American writer, Richard Wright.

Intentionality is characteristic of many psychological phenomena. It is commonly held by philosophers that intentionality cannot be ascribed to purely physical systems. This view does not merely deny that psychological language can be reduced to physiological language. It also claims that the appropriateness of some psychological explanation excludes the possibility of any underlying physiological or causal account adequate to explain intentional behavior. This is a thesis which I do not accept. I shall argue that physical systems of a specific sort (...) will show the characteristic features of intentionality. Psychological subjects are, under an alternative description, purely physical systems of a certain sort. The intentional description and the physical description are logically distinct, and are not intertranslatable. Nevertheless, the features of intentionality may be explained by a purely causal account, in the sense that they may be shown to be totally dependent upon physical processes. (shrink)